What is hyaluronic acid?

It is naturally an important component in the human body, especially in the extracellular matrix of connective, nerve and epithelial tissues, and also in skin, cartilage, joint (synovial) and eye fluids. Hyaluronic acid (HA) is one of the simplest members of a polysaccharide family, endogenous, chemically containing N-acetyl-D-glucosamine and D-glucuronic acid, and a sulfate-free glycosaminoglycan.
It shows rheological properties with an average molecular weight ranging from 0.1 - 10000 kDa, high molecular weight, water-soluble and a stable chain structure that does not linearly branch. Due to its viscoelastic structure, it has much higher water holding than other polymers. It neutralizes the pressure force in the body with water and ensures that the tissues are resistant to pressure. It has important functions such as signal transmission, nutrient carrier and substance passage through the matrix structure of the tissue. Moreover, it plays an important role in cell proliferation and spreading and increasing collagen synthesis. The amount of Hyaluronic acid in the body decreases with age, and this causes wrinkles on the skin. It directly affects the elasticity of the skin and the function of the joints. HA's unique rheological properties, biocompatibility and biodegradability are widely preferred in many biomedical, pharmaceutical and cosmetic applications such as medical implants and drug release.
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