BUGA-CoL Ultra Pure Type I Collagen Peptides From Bovine Tendon, BSE Free, Lyophilized
Product Information Ultrapure
BUGA-Ultra Pure Type I Collagen Peptides From Bovine Tendon, BSE Free, Lyophilized (BUGA-UpCol-I) is a product manufactured with medical-grade purity, setting the standard for all collagens in terms of purity (>99.9% collagen content), functionality, and natural collagen availability. BUGA-UpCol-I is produced in compliance with TSE EN ISO 22442 1-2-3 standards, using raw materials sourced from countries free of TSE/BSE status. The absence of TSE/BSE residues is certified through analysis, with test methods in accordance with the European Pharmacopoeia (EP 2.6.14 Method C) and the United States Pharmacopoeia (USP<85>).
BUGA-UpCol-I is a powdered form of collagen broken down into amino acids through factors such as acid, heat, or enzymes. Standard hydrolyzed collagen peptides typically have good purity levels but may contain additives or processing residues. In contrast, BUGA-UpCol-I is an ultra-pure hydrolyzed collagen, subjected to additional filtration and purification processes during production, achieving a high degree of purity. Its molecular weight ranges between 3-8 kDa. It is commonly used in the medical device sector for osteoarthritis treatments and the healing of skin wounds and burns. Additionally, it is preferred in the cosmetics industry for protein-based personal care and hair care products. In the food sector, it is used in the dietary supplements category.
• Medical Device Sector
• Osteoarthritis Treatment
• Cosmetics Industry
• Dietary Supplements
1. BUGA-UpCol-I can be easily used in your formulations thanks to its ability to dissolve easily in water.
2. Weigh the desired amount of powdered BUGA-UpCol-I collagen in an appropriate mixing container and let it slowly mix in pure water using a magnetic stirrer at the appropriate rpm.
3. Once fully dissolved, remove the product from the stirrer.
4. Use the solution in your formulations in the desired volumes.
5. You can store your solution at +4 ºC.
Product Technical Specifications
Appearance | Liyofilize beyaz toz |
Smell | No data available |
Ekstraksiyon yöntemi | Extraction method |
Sterilization method | Filtration |
Resolution | ≥ 95% in pure water |
Storage temperature | 15-25ºC |
Shelf life | 2 years from date of production |
Amino Acid Composition | ≥ %96 |
Degree of Hydrolyzation | ≥ %90 |
Molecular weight (SDS-PAGE) | 3000-8000 Dalton |
Source (Animal type) | Beef tendon |
E.coli (ISO 16649-2) | <10 kob/ml |
Mold-Yeast (ISO 21527-2) | <10 kob/ml |
Coagulase positive staphylococci (Staphylococcus aureus ve diğer türler-ISO 6888-1) | <10 kob/ml |
Aerobic Mesophilic Bacteria (ISO 4833-2) | <10 kob/ml |
• Chattopadhyay, S., & Raines, R. T. (2014). Collagen‐based biomaterials for wound healing. Biopolymers, 101(8), 821-833.
• Lupu, M. A., Gradisteanu Pircalabioru, G., Chifiriuc, M. C., Albulescu, R., & Tanase, C. (2020). Beneficial effects of food supplements based on hydrolyzed collagen for skin care. Experimental and therapeutic medicine, 20(1), 12-17.
• de Miranda, R. B., Weimer, P., & Rossi, R. C. (2021). Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta‐analysis. International Journal of Dermatology, 60(12), 1449-1461.
• Volpi, P., Zini, R., Erschbaumer, F., Beggio, M., Busilacchi, A., & Carimati, G. (2021). Effectiveness of a novel hydrolyzed collagen formulation in treating patients with symptomatic knee osteoarthritis: a multicentric retrospective clinical study. International Orthopaedics, 45, 375-380.
• Li, W., Kobayashi, T., Meng, D., Miyamoto, N., Tsutsumi, N., Ura, K., & Takagi, Y. (2021). Free radical scavenging activity of type II collagen peptides and chondroitin sulfate oligosaccharides from by-products of mottled skate processing. Food Bioscience, 41, 100991.
• Gu, Y., Zhang, J., Niu, Y., Sun, B., Liu, Z., Mao, X., & Zhang, Y. (2024). Virtual screening and characteristics of novel umami peptides from porcine type I collagen. Food Chemistry, 434, 137386.
• Dar, Q. A., Schott, E. M., Catheline, S. E., Maynard, R. D., Liu, Z., Kamal, F., ... & Zuscik, M. J. (2017). Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. PloS one, 12(4), e0174705.
• Guillerminet, F., Beaupied, H., Fabien-Soulé, V., Tomé, D., Benhamou, C. L., Roux, C., & Blais, A. (2010). Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone, 46(3), 827-834.
• De Luca, P., Colombini, A., Carimati, G., Beggio, M., de Girolamo, L., & Volpi, P. (2019). Intra-articular injection of hydrolyzed collagen to treat symptoms of knee osteoarthritis. A functional in vitro investigation and a pilot retrospective clinical study. Journal of clinical medicine, 8(7), 975.
