BUGA-Hyaluronic Acid from Rooster Comb Solutions (in pure water), 1 mg/ml
Product Info

Bugamed Biotechnology produces hyaluronic acid, which is in the glycosaminoglycan group, from rooster combs in high purity. BUGA-Hyaluronic Acid from Rooster Comb Solutions (in pure water), 1 mg/ml (BUGA-HYA-RC Solution), TS EN ISO standards are applied in the production. In this context, within the scope of MDR and medical device regulations, TS EN ISO 10993-10, 17 and 18 and biocompatibility tests ISO 10993-5 standards are followed. BUGA-HYA-RC Solution obtained from rooster combs has a high molecular weight (generally 2-4 MDa).
BUGA-HYA-RC Solution is a 1 mg/ml hyaluronic acid gel and has certain viscosity and flow properties. The viscosity of this solution varies depending on its molecular weight and concentration. BUGA-HYA-RC Solution with higher molecular weight generally tends to be more viscous and fuller, which allows it to persist in the tissue for a longer period of time. Solutions with a relatively lower molecular weight may have lower viscosity and are easier to inject. When injected, the gel structure helps to achieve the desired effect by providing a homogeneous distribution in the application area.
A 1 mg/ml concentration solution of rooster comb-derived hyaluronic acid in water is typically administered as a medical product via injection. Needle applications are utilized in fields such as dermatology, orthopedics, ophthalmology, and aesthetic surgery.
• Dermatology and Aesthetic Surgery
• Orthopedics
• Biomaterials
• Tissue engineering studies
• Cosmetic creams and moisturizers
• Wound healing
• Tissue regeneration
• Tissue renewal
• Biomaterial coatings
• The product is provided at a 1 mg/ml concentration in water and is ready for direct use.
• You can dilute the solution with pure water to achieve the desired concentration.
• The solution can be lyophilized to obtain it in dry form for your studies.
Product Technical Specifications
Appearance | Liquid, transparent color |
Smell | No data available |
Form | Solution |
Storage temperature | +4°C |
Shelf life | 3 months from production date |
Solubility/Hyaluronic acid concentration | Pure water/1 mg/ml |
Molecular weight | 2-4 MDa |
Viscosity (at 0.1% Concentration) | 0,17 Pa.s |
HA source | Sourced from rooster comb. |
Protein by Lowry | ≤ 2 % |
Endotoxin/LAL | ≤ 5 EU/ml |
Protein amount | ≤ % 0.1 |
Nucleic acid amount | ≤ % 0.01 |
Total amount of DNA and RNA | < 4,0 mg/ml |
Amount of fat | 0 |
• Graciela, C. Q., José Juan, E. C., Gieraldin, C. L., Xóchitl Alejandra, P. M., & Gabriel, A. Á. (2023). Hyaluronic Acid—Extraction Methods, Sources and Applications. Polymers, 15(16), 3473.
• Snetkov, P. P., Morozkina, S. N., & Uspenskaya, M. V. Hyaluronic Acid As A Polymer Matrix For Perspective Biomaterials.
• Rigo, D., da Silva, L. M., Fischer, B., Colet, R., Dallago, R. M., & Zeni, J. (2022). Hyaluronic Acid–from Production to Application: A.
• Strijder, L. R. (2020). The effects of Rooster Comb Extract on osteoarthritis pain in dogs (Master's thesis).
• Lambe, S., Ghogare, P., Sonawane, S., Shinde, L., & Prashant, D. (2021). Isolation, purification and characterization of hyaluronic acid: A concise review. Journal of Pharmacognosy and Phytochemistry, 10(3), 500-506.
• Solà, R., Valls, R. M., Martorell, I., Giralt, M., Pedret, A., Taltavull, N., ... & Martinez-Puig, D. (2015). A low-fat yoghurt supplemented with a rooster comb extract on muscle joint function in adults with mild knee pain: a randomized, double blind, parallel, placebo-controlled, clinical trial of efficacy. Food & function, 6(11), 3531-3539.
• Yoshioka, K., Katayama, M., Nishiyama, T., Harada, K., Takeshita, S., & Kawamata, Y. (2019). Biocompatibility study of different hyaluronan products for intra-articular treatment of knee osteoarthritis. BMC musculoskeletal disorders, 20, 1-9.
• Bernal, G., Solā, R. M., Casajuana, M. C., Pérez-Merino, L., Faba, J., González, R., ... & Giralt, M. Effect of rooster comb extract, rich in hyaluronic acid, on isokinetic parameters in adults with mild knee pain.
• Fallacara, A., Manfredini, S., Durini, E., & Vertuani, S. (2017). Hyaluronic acid fillers in soft tissue regeneration. Facial Plastic Surgery, 33(01), 087-096.
• Rigo, D., da Silva, L. M., Fischer, B., Colet, R., Dallago, R. M., & Zeni, J. (2022). Hyaluronic Acid–from Production to Application: A.