BUGA-CoL Undenatured Type I Collagen From Bovine Tendon, BSE Free, Lyophilized
BUGA-CoL Undenatured Type I Collagen From Bovine Tendon, BSE-Free, Lyophilized (BUGA-UC-I) is produced with medical-grade purity and sets the standard for all collagens in terms of purity (>99.9% collagen content), functionality, and the presence of natural collagen.
BUGA-UC-I is produced in compliance with TSE EN ISO 22442 1-2-3 standards, using raw materials sourced from countries free of TSE/BSE status. The absence of TSE/BSE residues is certified through analysis conducted using the European Pharmacopoeia (EP 2.6.14 Method C) and United States Pharmacopoeia (USP <85>) test methods.
BUGA-UC-I is an undenatured form of Type I collagen derived from bovine tendons. Extracted at low temperatures using acid/enzymatic methods, the collagen remains undenatured, preserving its integral structure. The product is lyophilized into a powdered form and easily dissolves in pure water. Compared to hydrolyzed collagen, it offers higher bioavailability and delivers maximum efficacy even at low doses.
• Biomaterial design
• Wound healing
• Joint health
• Food supplements
• Cosmetic formulations
1. Weigh the desired amount of BUGA-UC-I product and dissolve it in pure water or PBS solution at a neutral pH level, according to your preference.
2. Add the prepared BUGA-UC-I formulation to your desired concentration.
3. Store the solution at +4 ºC.
4. Note: You can add it to cosmetic formulations in powder form or as a solution.
5. Note: For food supplements, the recommended daily dose is 40 mg.
Technical Specifications of the Product
Appearance | Lyophilized white powder |
Smell | No data available |
Extraction method | Enzymatic/ Non-denatured |
Resolution | ≥ 95% in pure water |
Storage temperature | 15-25ºC |
Shelf life | 2 years from date of production |
Amino Acid Composition | ≥ %96 |
Degree of Hydrolyzation | ≥ %90 |
Molecular weight (SDS-PAGE) | 125 kDa |
Source (Animal type) | Beef tendon |
E.coli (ISO 16649-2) | <10 kob/ml |
Mold-Yeast (ISO 21527-2) | <10 kob/ml |
Coagulase positive staphylococci (Staphylococcus aureus and other species-ISO 6888-1) | <10 kob/ml |
Aerobic Mesophilic Bacteria (ISO 4833-2) | <10 kob/ml |
• Chattopadhyay, S., & Raines, R. T. (2014). Collagen‐based biomaterials for wound healing. Biopolymers, 101(8), 821-833.
• Henriksen, K., & Karsdal, M. A. (2024). Type I collagen. In Biochemistry of collagens, laminins and elastin (pp. 1-11). Academic Press.
• Rossert, J., & de Crombrugghe, B. (2002). Type I collagen: structure, synthesis, and regulation. In Principles of bone biology (pp. 189-XVIII). Academic Press.
• Maynes, R. (Ed.). (2012). Structure and function of collagen types. Elsevier.
• Orgel, J. P., Miller, A., Irving, T. C., Fischetti, R. F., Hammersley, A. P., & Wess, T. J. (2001). The in situ supermolecular structure of type I collagen. Structure, 9(11), 1061-1069.
