BUGA-Sodium Hyaluronate
Ürün Bilgisi
Buga-HA has a low molecular weight (generally 1 M-1.5 MDa).
BUGA-HYA is a polysaccharide generally used in medical, cosmetic and pharmaceutical fields. This compound is known for its high water retention capacity and forms a gel-like structure by interacting with water. It is also compatible with biological tissues and is the salt of hyaluronic acid naturally found in the body. The technical properties of BUGA-HYA include factors such as viscosity, molecular weight distribution, particle size and hydration ability. These properties may vary depending on the area where the product will be used and the purpose of application, but in general, it provides excellent water retention ability and biocompatibility.
• Biomedical
• Natural polymer for 3D printing
• Material Science
• Biochemistry and Cell culture studies
• Cosmetic creams and moisturizers
• Dermal filler products
• Osteoarthritis treatments
• Weigh BUGA-HYA according to your desired concentration.
• Add the weighed HA to pure water, sodium hydroxide solution, or PBS depending on your selected solvent, and mix until fully dissolved. This can be done using a mechanical or magnetic stirrer.
• To accelerate dissolution, you can mix at 50℃.
• Continue adding the appropriate solvent to reach the desired volume.
• For cross-linking studies, first activate the cross-linker with the solvent, then add BUGA-HYA and mix until the optimal mixture is achieved.
• Adjust the mixing temperature according to the activation degree of the cross-linker you are using.
• Store the prepared Sodium Hyaluronate product at +4°C or room temperature.
• Homogenization is not recommended for dense solutions; sodium hydroxide solution is advised for higher concentration studies.
• As the solution is highly viscous, using a mechanical stirrer is recommended.
• Bubbles may form during dissolution. It is observed that these bubbles dissipate after waiting for a period in experimental setups.
Product Technical Specifications
Appearance | Lyophilized white color |
Smell | No data available |
Form | White powder or granule |
Purity | ≥95,0 |
Storage temperature | 2-8 °C |
Shelf life | 2 years from date of production |
Resolution | Pure water, PBS or 0.1 M NaOH solution |
pH (in pure water) | 5,0-8,5 |
Molecular weight | 1,0-1,5 MDa |
HA source | Chemical Production |
Heavy metals | ≤20 ppm |
Bacterial count (CFU/g) | ≤100 |
Mold and yeast (CFU/g) | <50 |
Pseudomonas Aeruginosa | Negative |
Staphylococcus | Negative |
• Wang, X., Zhang, W., Zhou, Q., & Ran, F. (2023). Integrating supercapacitor with sodium hyaluronate based hydrogel as a novel All-In-One wound Dressing: Self-Powered electronic stimulation. Chemical Engineering Journal, 452, 139491.
• Xie, K., Pan, X., Huang, F., Ma, Y., Qi, Y., Wu, J., ... & Chen, Z. (2020). Needle knife therapy plus sodium hyaluronate injection for knee osteoarthritis: a protocol for a systematic review and meta-analysis. Medicine, 99(46).
• Chuc-Gamboa, M. G., Cámara Perera, C. M., Aguilar Ayala, F. J., Vargas-Coronado, R. F., Cauich-Rodríguez, J. V., Escobar-García, D. M., ... & San Román del Barrio, J. (2021). Antibacterial behavior of chitosan-sodium hyaluronate-PEGDE crosslinked films. Applied Sciences, 11(3), 1267.
• Liu, X., Hu, Y., Pan, Y., Fang, M., Tong, Z., Sun, Y., & Tan, S. (2021). Exploring the application and mechanism of sodium hyaluronate in cryopreservation of red blood cells. Materials Today Bio, 12, 100156.
• Musilová, L., Mráček, A., Azevedo, E. F., Valente, A. J., Cabral, A. M., Ribeiro, A. C., & Esteso, M. A. (2023). Interactions between Sodium Hyaluronate and β-Cyclodextrin as Seen by Transport Properties. International journal of molecular sciences, 24(3), 2889.
• Li, W., Zhao, X., Huang, T., Ren, Y., Gong, W., Guo, Y., ... & Tu, Q. (2021). Preparation of sodium hyaluronate/dopamine/AgNPs hydrogel based on the natural eutetic solvent as an antibaterial wound dressing. International Journal of Biological Macromolecules, 191, 60-70.
• Duan, Z. H., & Tang, Y. F. (2021). The clinical effects of sodium hyaluronate, polyethylene glycol, and dextran-70 eye drops in relieving dry eye after phacoemulsification. Medicine, 100(25).
• Belalcázar-Rey, S., Sanchez Huerta, V., Ochoa-Tabares, J. C., Altamirano Vallejo, S., Soto-Gómez, A., Suárez-Velasco, R., ... & Muñoz-Villegas, P. (2021). Efficacy and safety of sodium hyaluronate/chondroitin sulfate preservative-free ophthalmic solution in the treatment of dry eye: a clinical trial. Current Eye Research, 46(7), 919-929.
• Gong, X., Yao, H., & Wu, J. (2022). Sodium hyaluronate combined with rhEGF contributes to alleviate clinical symptoms and Inflammation in patients with Xerophthalmia after cataract surgery. BMC ophthalmology, 22(1), 1-10.
• Wang, X., Zhang, W., Zhou, Q., & Ran, F. (2023). Integrating supercapacitor with sodium hyaluronate based hydrogel as a novel All-In-One wound Dressing: Self-Powered electronic stimulation. Chemical Engineering Journal, 452, 139491.
